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Dgka

Assignment of the gene for diacylglycerol kinase DAGK to human chromosome Activation of alpha-diacylglycerol kinase is critical for the mitogenic properties of anaplastic lymphoma kinase. T cell anergy is reversed by active Ras and is regulated by diacylglycerol kinase-alpha.

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DGKA (diacylglycerol kinase, alpha 80kDa)

Bibliography Activation of alpha-diacylglycerol kinase is critical for the mitogenic properties of anaplastic lymphoma kinase. DGKA levels are tightly coupled to the differentiation and proliferation state of T lymphocytes. The deduced amino acid protein has a calculated molecular mass of The isoform described by Schaap et al. DGKA function might be crucial in the genesis and development dg,a several pathologies.

DGKA diacylglycerol kinase alpha [ (human)]

Tissue x Stage Matrix. Ada Hamosh - updated: It has 2 EF-hand motifs predicted to bind calcium, dtka cysteine-repeat regions, 2 putative ATP-binding sites, and a C-terminal stretch of amino acids that is fully conserved between human and pig DAGK. Entity Lung cancer Note Survival trees in a study involving the expression profiles of genes in lung adenocarcinoma patients identified DGKA ddgka a marker for good survival in a group of advanced-stage patients with remarkably good survival outcome Berrar et al.

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Available structures PDB Ortholog search: DGKA select the gene name Impact of mutations. Van Horn et al. Targeting of diacylglycerol degradation to M1 muscarinic receptors by beta-arrestins. Number of PDB entities unique chains for this gene: Homozygous mutation of this gene results in impaired induction of T cell anergy. The protein encoded by the DGKA gene 2.

Synthesis and phorbol ester binding of the cysteine-rich domains of diacylglycerol kinase DGK isozymes. The crystal structures rationalized extensive biochemical and biophysical data on the enzyme.

DGKA - diacylglycerol kinase alpha

The black lines connecting boxes represent introns. More reference expression data. The defining characteristic of type IV isozymes, such as DGK-zeta and -iotais that they dgkz C-terminal ankyrin repeats.

Assignment of the gene for diacylglycerol dgkka DAGK to human chromosome Chromosomal localization of three mouse diacylglycerol kinase DAGK genes: Molecular Function carbohydrate derivative binding cytoskeletal protein binding DNA binding enzyme regulator hydrolase ligase lipid binding oxidoreductase RNA binding signaling receptor activity signaling receptor binding transcription transferase transporter. Looking For More References?

Epub May Crystal structure of dgoa integral membrane diacylglycerol kinase. They were, however, at variance with the solution NMR model of van Horn et al. It also plays an important role in the resynthesis of phosphatidylinositols and phosphorylating diacylglycerol to phosphatidic acid.

In agreement with this finding, DGKA-overexpressing lymphocytes are "anergic" and no longer respond to antigenic stimuli Zha et al. Bound lipid substrate and docked ATP identified the putative dgkz site that is of the composite, shared site type.

Mammalian diacylglycerol kinases, a family of lipid kinases with signaling functions.

DGKA diacylglycerol kinase alpha [ (human)]

CATH Classification of proteins structures. T cell anergy is reversed by active Ras and is regulated by diacylglycerol kinase-alpha. View this region in JBrowse.

3 thoughts on “Dgka

  1. Tygogar

    Between us speaking, in my opinion, it is obvious. I would not wish to develop this theme.

    Reply

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